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Report regarding submission of the 2025 Genentech Annual Report for Planning Commission consideration. (Billy Gross, Principal Planner)
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RECOMMENDATION
Recommendation
Staff recommends that the Planning Commission review and accept the 2025 Genentech Annual Report pursuant to Chapter 20.260 of the South San Francisco Municipal Code.
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BACKGROUND/DISCUSSION
The Genentech Master Plan, which was updated in 2020, guides development of the Genentech 207-acre campus through the next planning horizon (anticipated to be 20 years or more). South San Francisco Municipal Code (SSFMC) Section 20.260.006 (Genentech Master Plan District Administration) requires that the Planning Commission reviews development activity within the Genentech campus at least once a year, and requires that Genentech submits an annual report which contains the following components, as appropriate:
• Status of facility-wide improvements
• Progress in completing the required tasks and benchmarks described in the implementation plan and / or Development Agreement
• Anticipated new construction or renovation projects
• An update on transportation and parking needs
• An update on mobile vendor (employee amenity) activities on the Genentech campus
• An update of the facility-wide transportation demand management (TDM) program
• Projected changes in the facility usage and requirements
• Advance notice of any proposed changes to the facility-wide development standards or design guidelines
• Notice of any changes that have been made to the facility master plan since the most recent annual report.
Campus Development and Buildout
Genentech has submitted an Annual Report for 2025 (Attachment 1 to this staff report), for Planning Commission review and consideration. The Annual Report provides updates on all the required components. The Annual Report notes that in 2025, no net new square footage was added to the campus. Other development activity was limited to upgrades and maintenance of existing facilities.
Leasing and Purchasing Activity
In 2025, Genentech modified the Genentech Master Plan to allow for privatization of select public campus roadways within the campus, including DNA Way, Point San Bruno Boulevard and one block of Cabot Road between Allerton Avenue and DNA Way. Genentech also purchased three private properties, 333 Point San Bruno Boulevard, 525 DNA Way and 383 East Grand Avenue. The City adopted a Zoning Map Amendment to rezone all three of the private properties and the former road rights-of-way to “Genentech Master Plan Zoning District”.
Transportation Demand Management and Parking
Genentech’s TDM program continues to show changes to commute patterns post-pandemic, with a smaller percentage of the overall work population commuting than pre-pandemic. Genentech’s overall mode split for 2025, including remote work and absences, was 59 percent, in keeping with the 59 percent reported in 2024 and 60 percent reported in 2023. Removing remote work and absences, the percentage of alternative transportation modes to the campus in 2025 was just above 33 percent, a reduction from 36 percent reported in 2024 and 39 percent reported in 2023.
Genentech’s Master Plan establishes a trip cap which limits daily AM peak hour single-occupancy vehicle (SOV) trips to no more than 5,216. Traffic cordon counts and parking surveys were conducted in late October 2025 to determine consistency with this trip cap. The cordon count reported an average of 1,718 AM peak hour SOV trips, well below the trip cap limit.
A parking inventory indicates that in 2025 Genentech had 6,446 parking spaces campus-wide, and parking occupancy was 61 percent, the same as reported in 2024 and less than the 70 percent occupancy reported in 2023.
CONCLUSION
Staff finds that the submitted report is consistent with the reporting requirements and recommends that the Planning Commission accept the 2025 Genentech Annual Report.
Attachment
1. 2025 Genentech Annual Report